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What We Know About the Use of Apoaequorin as a Nootropic

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When it comes to brain-boosting nootropics, some of the most intriguing supplements on the market right now are those containing apoaequorin, a protein found in certain species of jellyfish (namely glow-in-the-dark ones). As this is generating so much interest in the field of neurological health lately, let’s take a look at what you need to know about apoaequorin, including the benefits, potential side effects and more.

A closer look at apoaequorin

One of the top brands containing this ingredient is Prevagen, an over-the-counter dietary supplement in the nootropics category that boasts the ability to help target brain function in relation to the effects of ageing. Just to clarify what nootropics are, these are naturally-derived ‘smart drugs’ taken by individuals to improve focus, memory, alertness and more. There can be many reasons why these mental processes can see a decline, but it’s no secret that a lot of them can become more prevalent with age. This is the main focus for apoaequorin, and its preferred use is to treat age-related issues over improving general productivity.

One of the leading causes of mental decline is thought to be related to calcium buildup in the brain. As apoaequorin binds with calcium, there’s evidence to suggest that it could potentially minimise deposits and reduce the speed of brain deterioration.

The benefits of apoaequorin

Initial benefits include improved memory with long-term use (taking a daily supplement for a period of 90 days), better cognitive recall and an increase in verbal learning. There are currently a number of studies to determine its future use in treating dementia and Alzheimer’s disease, but it is also showing signs of improving sleep quality, reducing anxiety and even boosting moods (so there may be applications for depression).

Potential side effects

When you begin taking natural supplements, sometimes side effects can occur. The ones associated with those containing apoaequorin are headaches, dizziness, nausea and constipation, but these are typically temporary and will subside over time (if they occur at all). It is always advisable to speak to a healthcare professional before adding supplements to your diet, as they can give you worthwhile advice and determine if any of the ingredients may negatively interact with any medications you may be currently taking.

Is apoaequorin allergy safe?

As this ingredient has been growing in popularity, there has been a host of safety checks undertaken to ensure that it is allergy safe. The good news is that in human-based trials, it has held up well in cycles of 90 days and is showing no signs of adverse effects both in those with and without preexisting allergies.

How to take apoaequorin

For older individuals who want to improve brain function and overall boost their memory and cognitive function, nootropic supplements that contain apoaequorin (like Prevagen) come in three strengths: 10 mg (regular), 20 mg (extra-strength), and 50 mg (so-called professional-strength) formulations. These supplements are taken once a day and typically in the morning, for the best results.

Prevagen regular strength comes in different flavours (regular, mixed berry and orange), extra strength comes in mixed berry flavour and the professional formula comes in regular flavour. If you decide to take this supplement, it can be worthwhile to start off with the lowest dosage and work your way up as you see fit. Again, always consult with a medical professional before starting a new supplement.

Final thoughts

When it comes to using nootropics to improve brain function, supplements like Prevagen may be a wiser choice over other blends when ageing is a concern. There isn’t much evidence supporting just how effective apoaequorin is, but the fact that there are little to no side effects and that it’s allergy-safe means that it could be worth a try to see if provides assistance for the right users.

It’s not a new supplement on the market and as a result, there are plenty of reviews and testimonials out there, so it should be simple enough to find some real user opinions that will help you to decide if it will be the right one for you if you are concerned about mental decline.


Zuella Montemayor did her degree in psychology at the University of Toronto. She is interested in mental health, wellness, and lifestyle. 

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