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What Are the Side Effects of Gabapentin

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Gabapentin is a medication commonly prescribed for conditions such as epilepsy, nerve pain, and anxiety. Originally developed to mimic the neurotransmitter gamma-aminobutyric acid (GABA), it works by affecting the activity of certain nerve cells in the brain and spinal cord. While gabapentin can be effective in treating a variety of conditions, it is not without its side effects. As with any medication, it’s essential to be aware of the potential side effects, how to manage them, and when to seek medical advice.

Common side effects you should know about

Some of the most commonly reported side effects of gabapentin include:

  • Dizziness
  • Fatigue
  • Weight gain
  • Drowsiness
  • Peripheral oedema (swelling of extremities)

These symptoms are generally mild and may dissipate over time as your body adjusts to the medication. However, it’s important to note that the severity and duration of side effects can vary from person to person.

Less common but serious side effects

While the aforementioned symptoms are relatively benign, gabapentin can also cause more serious side effects, such as:

  • Respiratory issues like shallow breathing
  • Serious rash or allergic reactions
  • Changes in behaviour or mood, including suicidal thoughts

If you experience any of these symptoms, it’s crucial to seek medical attention immediately.

Are there any long-term consequences?

Long-term use of gabapentin has been associated with certain risks, including dependency and withdrawal symptoms like insomnia, nausea, and sweating. For this reason, it is crucial to follow the prescription and guidelines provided by your healthcare provider, who may regularly review and adjust your dosage.

How to manage the side effects

Here are some tips to manage the side effects effectively:

  • Consult your healthcare provider. If you’re experiencing any unusual symptoms, it’s best to consult your healthcare provider for personalised advice.
  • Stay hydrated. This can help alleviate symptoms like dizziness and fatigue.
  • Take it easy. Try to avoid activities that require mental alertness, such as driving, when you first start taking gabapentin.
  • Monitor your weight. If weight gain becomes a concern, discuss dietary and exercise strategies with your healthcare provider.

Interactions with other substances

Gabapentin may interact with other substances, including alcohol and over-the-counter medications. These interactions can either potentiate or mitigate the side effects. Always check with your healthcare provider before combining gabapentin with other medications or substances.

When to consult a healthcare provider

Consult your healthcare provider if:

  • You experience severe or lasting side effects.
  • Your symptoms worsen over time.
  • You are concerned about the long-term implications of taking gabapentin.

Your healthcare provider may adjust your dosage or recommend alternative treatment options.


While gabapentin can offer relief for various conditions, being aware of its potential side effects is essential for safe and effective use. Always consult your healthcare provider for personalised advice tailored to your specific needs.

Sarah Johnson is a healthcare journalist with over a decade of experience in medical writing and research.

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