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What Are the Side Effects of Amlodipine

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As a commonly prescribed medication for managing high blood pressure (hypertension) and certain heart conditions, amlodipine has become an essential component of many treatment plans. Belonging to the calcium channel blocker (CCB) class of drugs, it helps relax blood vessels, allowing for smoother blood flow and a reduced workload for the heart. But like any medication, amlodipine comes with its own set of potential side effects. 

Common side effects of amlodipine

  • Swelling. One of the most frequent side effects experienced by amlodipine users is peripheral oedema, or swelling in the lower legs, ankles, and feet. This occurs due to fluid retention and typically resolves on its own. However, if the swelling becomes severe, persistent, or accompanied by sudden weight gain or difficulty breathing, it is crucial to consult your healthcare provider.
  • Dizziness. Amlodipine can cause dizziness or lightheadedness, particularly in the initial stages of treatment or when adjusting dosages. To minimize this side effect, it is advisable to rise slowly from a sitting or lying position and to avoid sudden movements. If dizziness persists or worsens, contact your healthcare provider.
  • Headaches. Some individuals may experience headaches while taking amlodipine. Over-the-counter pain relievers, such as acetaminophen or ibuprofen, can help alleviate the discomfort. But if headaches become severe or persistent, consult your healthcare provider.
  • Fatigue. Amlodipine users may feel fatigued or experience a general sense of weakness. This side effect usually diminishes over time, but if it persists or worsens, it is essential to discuss it with your healthcare provider.
  • Palpitations. Occasionally, amlodipine can cause heart palpitations or a sensation of rapid or irregular heartbeats. While this side effect is typically not harmful, it is essential to report it to your healthcare provider, especially if you have a history of heart conditions.

Rare and severe side effects of amlodipine

While less common, some amlodipine users may experience more severe side effects that warrant immediate medical attention. These include:

  • Allergic reactions. Although rare, some individuals may experience an allergic reaction to amlodipine. Symptoms can include rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you suspect an allergic reaction, seek emergency medical care.
  • Chest pain or angina. In some cases, amlodipine can cause or worsen chest pain or angina. This may be more likely to occur when first starting the medication or when increasing the dosage. If you experience new or worsened chest pain, consult your healthcare provider immediately.
  • Severe hypotension. Amlodipine may cause a significant drop in blood pressure, leading to severe hypotension. Symptoms include extreme dizziness, fainting, and a weak, rapid pulse. If you suspect severe hypotension, seek emergency medical care.
  • Liver problems. Although uncommon, amlodipine can cause liver problems. Signs of liver issues include dark urine, persistent nausea or vomiting, stomach pain, yellowing of the eyes or skin (jaundice), and extreme fatigue. If you experience any of these symptoms, contact your healthcare provider immediately.
  • Severe skin reactions. In rare cases, amlodipine can cause serious skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. These conditions are characterised by symptoms like fever, severe skin rash, blisters, peeling skin, and mouth sores. If you develop any of these symptoms, stop taking amlodipine and seek immediate medical attention.

Managing side effects and precautions

To minimize the risk of side effects, it is crucial to take amlodipine exactly as prescribed by your healthcare provider. Here are some general precautions to keep in mind:

  • Do not stop taking amlodipine suddenly, as this may cause a rebound increase in blood pressure or worsen heart-related symptoms. If you need to discontinue the medication, your healthcare provider will guide you on how to taper off the drug safely.
  • Inform your healthcare provider of all medications, supplements, and herbal products you are taking, as certain substances may interact with amlodipine and increase the risk of side effects.
  • If you are pregnant or planning to become pregnant, discuss the potential risks and benefits of taking amlodipine with your healthcare provider. Amlodipine should only be used during pregnancy if the benefits outweigh the risks.
  • Stay hydrated and avoid excessive alcohol consumption while taking amlodipine, as these factors can contribute to dizziness and an increased risk of hypotension.
  • Monitor your blood pressure regularly and report any unusual symptoms or concerns to your healthcare provider.


Amlodipine is a widely prescribed and generally well-tolerated medication for managing high blood pressure and certain heart conditions. While some side effects are common and typically mild, it is essential to be aware of the rarer, more severe side effects that warrant medical attention. By following your healthcare provider’s instructions and taking precautions, you can minimize the risk of side effects and ensure a safe and effective treatment experience.

Robert Haynes, a psychology graduate from the University of Hertfordshire, has a keen interest in the fields of mental health, wellness, and lifestyle.

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