People with Down syndrome are likely to develop Alzheimer’s disease at a young age, with autopsy studies showing that by age 40, the brains of individuals with Down syndrome have amyloid plaques. Yet people with Down syndrome have been excluded from or under-represented in clinical trials of new therapies for treating AD. The US Food and Drug Administration has approved lecanemab to treat AD at an early stage of the disease because it has demonstrated the ability to target and remove beta-amyloid plaques.
A new study led by investigators at Brigham and Women’s Hospital (a founding member of the Mass General Brigham healthcare system) and the University of California, Irvine, tested lecanemab to see if it could bind to amyloid plaques in tissue samples from people with Down syndrome, finding that it effectively targeted amyloid in all 15 samples. But the drug is also bound to brain blood vessels, which raises safety concerns. The results are published in JAMA Neurology.
“Our study is highly clinically relevant, as we focus on the usage of a recently approved disease-modifying therapy for Alzheimer’s disease, lecanemab, in people with Down syndrome,” said co-corresponding author Lei Liu, MD, of the Department of Neurology at Brigham and Women’s Hospital.
“Our findings underscore the exciting promise of anti-amyloid drugs for helping people with Down syndrome, but also the need for careful consideration of safety, especially the risk of hemorrhagic complications,” said co-corresponding author Elizabeth Head, PhD, of the Department of Pathology and Laboratory Medicine at the University of California, Irvine.
The research team evaluated brain tissue samples from 15 people with Down syndrome who were between the ages of 43 and 68 years old. The study was limited in its sample size and age range; in the future, the researchers hope to expand the study to include samples from younger brain donors to determine if age may be a factor in the drug binding to blood vessels. The team also plans to evaluate the drug’s binding profile in people with late-onset AD to see if it follows a similar pattern. The research team expresses its gratitude to people with Down syndrome for their gift of brain donation.
