‘Although many people try illicit drugs like cocaine or heroin, only a small proportion develop an addiction,’ said lead author Morgan James, a member of the Rutgers Brain Health Institute and an assistant professor in the department of psychiatry at Rutgers Robert Wood Johnson Medical School. ‘The interaction found between sensation-seeking traits and the drug-taking experience show that predisposition to addiction has a genetic basis, and that this interacts with environmental factors such as patterns of drug use. The sensation-seeking trait was predictive of rats’ likelihood to exhibit stronger motivation for drugs when we gave them the opportunity to take cocaine.’
The findings, published in the journal Neuropharmacology, shed light on what predisposes people to addiction and may help with substance use screening and treatment.
The lab study found that high sensation-seeking rats – those with a strong desire for new experiences and a willingness to take risks to be stimulated – were more prone to developing behaviour that reflects human addiction. The findings suggest that high sensation-seeking people have a greater risk of losing control over their drug intake, which makes them more vulnerable to drug addiction.
A major goal of addiction research is to identify behavioural biomarkers that predict addiction vulnerability. Future studies can build on these findings to determine what is different in the brains of those who are high sensation-seeking to see what predisposes them to addiction.
Disclaimer: Psychreg is mainly for information purposes only. Materials on this website are not intended to be a substitute for professional advice, diagnosis, medical treatment, or therapy. Never disregard professional psychological or medical advice nor delay in seeking professional advice or treatment because of something you have read on this website. Read our full disclaimer here.