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Peptide and Drug Development: Everything You Need to Know

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1922 marked the beginning of the peptide therapeutics field, when insulin was first used as a medicine. Peptides are crucial elements of biological pathways in the body and are composed of short amino acid chains. When considered as a drug molecule, often they have a particular selectivity and potency.

Pharmaceutical peptides play a crucial role in the medical field. Years of research have reflected that these peptides can have an advantageous impact on the industry. There are many reasons why researchers buy peptides for their medicinal research. In this blog, we will look at what you need to know about peptides and drug development.

How are peptide drugs made?

In recent decades, breakthroughs in peptide synthesis technology have made it possible to manufacture synthetic peptide drugs with high purity and yield, making them more accessible. Here are some examples of these latest procedures:

  • SPPS (solid-phase peptide synthesis). SPPS is concerned with building the peptide chain on a solid support that enables the selective removal of protecting groups in addition to new amino acids. The process starts with the addition of the first amino acid to the solid support, then it continues by adding additional amino acids repeatedly. After that, the peptide is cleaved from the solid support and purified through different procedures, such as HPLC.
  • Microwave-assisted peptide synthesis. It is a comparatively new method that has gained popularity in recent years. This procedure concerns using microwave radiation to accelerate the peptide synthesis procedure. This radiation generates heat uniformly and rapidly, decreasing the reaction time and increasing the yields. This method is very efficient and highly effective for synthesising complex peptides, such as those with cyclic structures and high hydrophobicity.
  • Automated peptide synthesisers. The automated peptide synthesisers are computer-managed pumps that add the required reagents and amino acids, eliminating the need for manual intervention and decreasing the chance of errors. The machines also have built-in purification systems, which can purify the peptides in real time, saving resources and time.

The benefit of using peptides in drug development

Peptides have been used in drug development since the discovery of insulin. During the last century, we have identified various advantages to the use of peptides in drug development and the production method.

Compared with other biological agents, peptides come with a longer shelf life and marvellous stability at room temperature. Additionally, the absence of superstructure makes it impossible for them to denaturalize. Peptides are obtained through chemical synthesis, not based on cellular activity, as in this case, with complete proteins. This makes the production easy and cheap.

Other than that, chemical synthesis enables the introduction of certain modifications to the chain and the creation of cyclic peptides.

Wrapping up

Ever since insulin, peptides in the pharma industry have reached many milestones. These days, peptides and drug development go hand in hand. However, if there is one thing that is more important than drug development, it is the quality of the materials that go into drug development. If you wish to stay unhinged with the quality of your peptides, check out Lotilabs today.

Ellen Diamond, a psychology graduate from the University of Hertfordshire, has a keen interest in the fields of mental health, wellness, and lifestyle.

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