A recent University of Kentucky Markey Cancer Center study suggests a new radiopharmaceutical compound may be a viable treatment option for patients with advanced cervical cancer.
The study, led by UK Markey Cancer Center radiation oncologist Charles Kunos, MD, and published in the journal Frontiers in Oncology, validates that the radioactive drug 212Pb-DOTAM-GRPR1 may be useful in the treatment of persistent, recurrent, or metastatic cervical cancer.
Radiopharmaceuticals are expected to play an increasingly important role in the future of cancer treatment. They deliver radiation therapy directly to cancer cells, reducing the risk of damage to healthy tissue and resulting in improved treatment outcomes and reduced side effects compared to typical radiation therapy.
“As researchers develop new radiopharmaceutical agents, part of the clinical validation of these efforts is to provide proof that the targets are present in the cancer cells,” said Kunos, a professor of radiation medicine at the University of Kentucky College of Medicine. “This study ensures that clinical trials using this agent have the best chance to be successful, which will ultimately bring these advanced therapies to the greater oncology market.”
Radiopharmaceuticals require a molecular target to deliver therapy to tumours. 212Pb-DOTAM-GRPR1 targets gastrin-releasing peptide receptor (GRPR), a protein expressed by cancer cells.
Kunos’ team evaluated tissue from 33 tumours from women who had metastatic cervical cancer. Most of the tissue studied overexpressed the GRPR, suggesting 212Pb-DOTAM-GRPR1 is a promising therapy to treat the disease.
“As Kentucky has the highest incidence and mortality rate of cervical cancer in the US, the University of Kentucky has a vested interest in finding new therapies for the disease,” said Kunos. “Many of our patients are often presented with a much later stage disease and have the greatest need for a new targeted therapy like a radiopharmaceutical.”
The results also validate a phase 1 clinical trial of 212Pb-DOTAM-GRPR1 that is already underway at Markey.
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