Home Health & Wellness New Study Reveals Lifestyle Changes Could Help Delay Ageing’s Epigenetic Effects and Extend Healthspan

New Study Reveals Lifestyle Changes Could Help Delay Ageing’s Epigenetic Effects and Extend Healthspan

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The World Health Organization has projected a significant increase in the number of people over 60 years of age worldwide by 2050, from 1 billion in 2019 to 2.1 billion, emphasising the urgent need for strategies to ensure a healthy longevity. To tackle this issue, a team of researchers from the ALFA Score Consortium, University of Algarve Campus Gambelas, William Osler Health System, and Champalimaud Centre for the Unknown has explored the promotion of healthspan from an epigenetic perspective in a new study. The findings were published in the journal Aging

Epigenetic phenomena can be modified in response to environmental exposures, connecting an individual’s environment to their gene expression pattern. Epigenetic studies have revealed that aging is associated with the decondensation of chromatin, leading to an altered heterochromatin structure that promotes the accumulation of errors.

In their research, the team discusses aging and its associated epigenetic changes, as well as how these changes may be delayed or reversed through nutrition, caloric restriction, and sustained physical activity. They also suggest that age-associated epigenetic events are less common in individuals who maintain a healthy lifestyle, including balanced nutrition, caloric restriction, and physical exercise. Such healthy aging is associated with more tightly condensed chromatin, fewer post-translational modifications, and greater regulation by non-coding RNAs.

The study highlights the importance of epigenetic mechanisms in aging and suggests that lifestyle interventions can delay or even reverse age-associated epigenetic changes, offering hope for improving healthspan and ensuring healthy longevity in the future.

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