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NAD+ and Chronic Stress

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Millions of people silently suffer from chronic stress, which has become an epidemic that leads to widespread fatigue, worry, despair, and a host of other health problems. The good news is that cellular energy can be powerfully restored, stress-related damage can be repaired, and health can be corrected at the innovative NAD IV therapy clinic.

The devastating effects of chronic stress

The stress response is initiated by hormones, specifically cortisol and adrenaline, triggered in reaction to a perceived threat. Whether facing a grizzly bear in the woods or racing against a work deadline, the fundamental nature of the stress response remains consistent. The brain swiftly activates an alert system throughout the body, preparing it for immediate action.

The initial chemical reaction to acute stress commences with the activation of limbic pathways, stimulating the sympathetic-adrenal-medullary axis and the renin-angiotensin system. These systems provide energy and heighten sensory perception, making individuals hyper-aware of their surroundings. Neuropeptides, adrenaline, and other hormones governing cardiovascular and metabolic functions flood the system. Heart and respiratory rates increase, and glucose is released to provide additional energy for confronting or escaping the threat.

In a typical response to acute stress, the body’s chemistry swiftly returns to a resting state once the threat is resolved. Hormone levels normalise, heart and respiratory rates decrease, and heightened awareness diminishes. However, when stress persists and remains unresolved, the chemical mediators of stress remain elevated. Over time, chronic stress can compromise the immune system and damage tissues and vital organs at the cellular level.

Consequently, long-term stress has been linked to both mental and physical health issues. It underscores the importance of identifying effective strategies to manage stress and maintain overall well-being. Managing stress becomes crucial to preserving cellular health and mitigating the potential consequences associated with depleted NAD+ levels.

Introducing NAD+: a vital anti-stress molecule

NAD+ is pivotal in numerous cellular processes, including energy production, DNA repair, immune system regulation, and inflammation reduction. Research indicates chronic stress can deplete NAD+ levels, disrupting the delicate equilibrium between NAD+ and NADH. This depletion can potentially induce mitochondrial dysfunction, hindering cellular energy production. Without sufficient NAD+, cells struggle to function efficiently, giving rise to various health issues.

A study published in Molecular Metabolism highlighted that alterations in the NAD+/NADH ratio or the overall NAD+ pool size might result in maladaptation within the biological system, potentially contributing to various neurodegenerative disorders, aging, and tumorigenesis.

Supplementation with NAD+ emerges as a transformative intervention. Another study investigating the impact of exogenous NAD+ supplementation in the context of age-related macular degeneration (AMD) revealed its ability to reduce oxidative stress and enhance autophagy. This suggests a potential therapeutic value in AMD, as autophagy is a crucial cellular process responsible for breaking down damaged and senescent cells and promoting the generation of new and healthy cells.

In summary, we stand at the frontier of a NAD+ revolution. Harnessing this vital molecule promises to alleviate much human suffering from pervasive stressors. Those ready to transcend the current pandemic of fatigue, anxiety, and accelerated ageing have a powerful ally in NAD IV therapy.




David Radar, a psychology graduate from the University of Hertfordshire, has a keen interest in the fields of mental health, wellness, and lifestyle.

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