< 1 MIN READ | Cognitive Psychology

Signals From Muscle Protect From Dementia

Cite This
, (2021, March 26). Signals From Muscle Protect From Dementia. Psychreg on Cognitive Psychology. https://www.psychreg.org/muscle-protect-dementia/
Reading Time: < 1 minute

How do different parts of the body communicate? Scientists at St Jude are studying how signals sent from skeletal muscle affect the brain.

The team studied fruit flies and cutting-edge brain cell models called organoids. They focused on the signals muscles send when stressed. The researchers found that stress signals rely on an enzyme called Amyrel amylase and its product, the disaccharide maltose.

The scientists showed that mimicking the stress signals can protect the brain and retina from ageing. The signals work by preventing the buildup of misfolded protein aggregates. Findings suggest that tailoring this signaling may potentially help combat neurodegenerative conditions like age-related dementia and Alzheimer’s disease.

‘We found that a stress response induced in muscle could impact not only the muscle but also promote protein quality control in distant tissues like the brain and retina,’ said Fabio Demontis, PhD, of St Jude Developmental Neurobiology. ‘This stress response was actually protecting those tissues during ageing.’


Disclaimer: Psychreg is mainly for information purposes only. Materials on this website are not intended to be a substitute for professional advice, diagnosis, medical treatment, or therapy. Never disregard professional psychological or medical advice nor delay in seeking professional advice or treatment because of something you have read on this website. Read our full disclaimer here

Copy link