In a new study of patients with autism who are 18 years old and under, researchers from Ben-Gurion University of the Negev (BGU) and Soroka University Medical Center report that cannabis as a treatment for autism spectrum disorders appears to be a well-tolerated, safe and effective option to relieve symptoms including seizures, tics, depression, restlessness and rage attacks.
In the study published in Nature Scientific Reports, Lihi Bar-Lev Schleider, of the BGU-Soroka Clinical Cannabis Research Institute, comments: ‘Overall, more than 80% of the parents reported significant or moderate improvement in their child.’
Autistic spectrum disorder (ASD) is an extensive developmental disorder that is expressed in almost all dimensions of the child’s development. It is now common to refer to this disorder as a wide range of pervasive developmental disorders (PDD) in which there are various manifestations and symptoms.
According to BGU’s Dr. Gal Meiri of the Negev Autism Center: ‘We analysed the data prospectively collected as part of the treatment programme of 188 ASD patients treated with medical cannabis between 2015 and 2017. The treatment in majority of the patients was based on cannabis oil containing 30% cannabidiol oil (CBD) and 1.5% tetrahydrocannabinol(THC). Symptoms, patient global assessment and side effects at six months were primary outcomes of interest and were assessed by structured questionnaires.’
Overall, after six months of treatment, 30% of patients reported a significant improvement, 53.7% reported moderate improvement, and only 15% had slight or no change.
Quality of life, mood and ability to perform activities of daily living were assessed prior to treatment and at six months. Good quality of life was reported by 31.3% of patients prior to treatment initiation. At six months, good quality of life more than doubled to 66.8% . Positive mood was reported as 42% before treatment and 63.5 after six months.
The ability to dress and shower independently improved significantly from cannabis treatment. Only a quarter (26.4%) reported no difficulty prior to the treatment while 42.9% improved their ability to dress and shower independently at six months.
Cannabis oil medication also significantly improved sleep and concentration. Good sleep and concentration were reported by 3.3% and 0% respectively at the outset vs 24.7% and 14% during an active treatment.
‘While this study suggest that cannabis treatment is safe and can improve ASD symptoms and improve ASD patients’ quality of life, we believe that double blind placebo-controlled trials are crucial for a better understanding of the cannabis effect on ASD patients,’ says Dr. Victor Novack, of the BGU-Soroka Clinical Cannabis Research Institute.
The study was funded by Tikun Olam. Other researchers that participated in the study include: Raphael Mechoulam, The Hebrew University of Jerusalem; and Naama Saban, Tikun Olam.
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