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High Fructose Intake May Drive Aggressive Behaviours, ADHD, and Bipolar

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New research suggests that conditions such as attention deficit hyperactivity syndrome (ADHD), bipolar disorder, and even aggressive behaviours may be linked with sugar intake and that it may have an evolutionary basis.

The research, from the University of Colorado Anschutz Medical Campus and published in the journal Evolution and Human Behavior, presents a hypothesis supporting a role for fructose, a component of sugar and high fructose corn syrup, and uric acid (a fructose metabolite), in increasing the risk for these behavioural disorders.

‘We present evidence that fructose, by lowering energy in cells, triggers a foraging response similar to what occurs in starvation,’ said lead author Richard Johnson, MD, professor at the University of Colorado School of Medicine on the CU Anschutz Medical Campus.

Johnson outlines research that shows a foraging response stimulates risk-taking, impulsivity, novelty-seeking, rapid decision-making, and aggressiveness to aid the securing of food as a survival response. Overactivation of this process from excess sugar intake may cause impulsive behaviour that could range from ADHD to bipolar disorder or even aggression.

‘While the fructose pathway was meant to aid survival, fructose intake has skyrocketed during the last century and may be in overdrive due to the high amounts of sugar that are in the current Western diet,’ Johnson adds.

The paper looks at how excessive intake of fructose present in refined sugars and high fructose corn syrup may have a contributory role in the pathogenesis of behavioural disorders that are associated with obesity and the Western diet.

Johnson notes: ‘We do not blame aggressive behaviour on sugar, but rather note that it may be one contributor.’

Johnson recommends further studies to investigate the role of sugar and uric acid, especially with new inhibitors of fructose metabolism on the horizon.

‘The identification of fructose as a risk factor does not negate the importance of genetic, familial, physical, emotional and environmental factors that shape mental health,’ he adds.

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