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Why a High Fat Diet Could Reduce the Brain’s Ability to Regulate Food Intake?

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Regularly eating a high-fat/calorie diet could reduce the brain’s ability to regulate calorie intake.

New research in rats found that after short periods of being fed a high-fat/high-calorie diet, the brain adapts to what is being ingested and reduces the amount of food eaten to balance calorie intake.

The researchers from Penn State College of Medicine, US, suggest that calorie intake is regulated in the short-term by cells called astrocytes (large star-shaped cells in the brain that hold many different functions of neurons in the brain) that control the signalling pathway between the brain and the gut. Continuously eating a high-fat/calorie diet disrupts this signalling pathway.

Understanding the brain’s role and the complex mechanisms that lead to overeating, a behaviour that can lead to weight gain and obesity, could help develop therapies to treat it. Obesity is a global public health concern associated with an increased risk of cardiovascular diseases and type 2 diabetes.

In England, 63% of adults are considered above a healthy weight and around half of these are living with obesity. One in three children leaving primary school is overweight or obese.

Dr Kirsteen Browning, Penn State College of Medicine, US, said: “Calorie intake seems to be regulated in the short-term by astrocytes. We found that a brief exposure (three to five days) to a high fat/calorie diet has the greatest effect on astrocytes, triggering the normal signalling pathway to control the stomach.”

“Over time, astrocytes seem to desensitise to high-fat food. Around 1014 days of eating a high fat/calorie diet, astrocytes seem to fail to react, and the brain’s ability to regulate calorie intake seems to be lost. This disrupts the signalling to the stomach and delays how it empties.”

Astrocytes initially react when high-fat/calorie food is ingested. Their activation triggers the release of gliotransmitters, chemicals (including glutamate and ATP) that excite nerve cells and enable normal signalling pathways to stimulate neurons that control how the stomach works.

This ensures the stomach contracts correctly to fill and empty in response to food passing through the digestive system. When astrocytes are inhibited, the cascade is disrupted. The decrease in signalling chemicals leads to delayed digestion because the stomach doesn’t fill and empty appropriately.

The vigorous investigation used behavioural observation to monitor food intake in rats (N=205, 133 males, 72 females) fed control or high fat/calorie diet for one, three, five or 14 days. This combined pharmacological and specialist genetic approaches (both in vivo and in vitro) to target distinct neural circuits.

Enabling the researchers to specifically inhibit astrocytes in a particular region of the brainstem (the posterior part of the brain that connects the brain to the spinal cord), so they could assess how individual neurons behaved to studying rats’ behaviour when awake.

Human studies will need to be conducted to confirm if the exact mechanism occurs in humans. If this is the case, further testing will be required to assess if the tool could be safely targeted without disrupting other neural pathways.

The researchers have plans to explore the mechanism further. Dr Kirsteen Browning said: “We have yet to find out whether the loss of astrocyte activity and the signalling mechanism is the cause of overeating or that it occurs in response to the overeating.”

“We are eager to determine whether it is possible to reactivate the brain’s lost ability to regulate calorie intake. If this is the case, it could lead to interventions to help restore human calorie regulation.”

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