Cellulite is a massive skincare concern for many as it affects 80% of women. While scientists do not fully understand the exact molecular mechanisms of cellulite, cellulite is described as a complex skin disorder that involves the bulging of subcutaneous fat into the middle layer of the skin (the dermis). This results in structural, inflammatory, and biochemical changes in the skin, dimpling, and lumps on the skin’s surface.

While cellulite cannot be cured, it can dramatically reduce its appearance. To date, most remedies are either utterly ineffective as they cannot reach target sites within the skin or fat tissue, or they are costly, invasive, and inconsistent in their results.

Reducing cellulite involves altering the fat tissue, skin collagen content and connective tissue. ​Next-generation technologies include highly bioavailable nutraceutical supplements and cosmeceutical skincare technologies that can do just this.

Dermoi’s Chief Scientific Officer Eve Casha, MSc in Pharmaceutical Formulation, outlines clinically-proven technologies for the improvement of cellulite.

Skinade cellulite

Skinade Cellulite provides a multifaceted approach to the improvement of cellulite. This is due to its highly bioavailable liquid, micro solid in suspension, and powder activator formulation, introducing 19 actives deep into the skin. ​ It increases dermal integrity, hormone balance, microcirculation, and metabolism while reducing water retention, inflammation, and protrusion of fat tissue into the skin.

Skinade Cellulite combines scientifically studied collagen peptides, which act on fibroblast cells to stimulate dermal remodelling, with a patented, plant-based superoxide dismutase called TSC active. ​ TSC active reveals firmer, smoother skin with reduced lumpiness and dimpling. It has shown a visible reduction in cellulite by 10% in 28 days in randomised, double-blind, placebo-controlled clinical trials with 41 women. ​

Evenswiss

Evenswiss is the creator of patented cosmeceutical and pharmaceutical technology Dermatopoietin. Dermatopoietin is equivalent to a signalling protein naturally found in the skin (human epidermal cytokine interleukin 1-alpha). ​ It generates a strong signalling cascade from the skin’s surface into the dermis to stimulate intense regeneration. ​Dermatopoietin thickens the skin by increasing collagen, elastin, and hyaluronic acid by up to 90% in two weeks.

Dermatopoietin strengthens the skin and increases the integrity of its dermal tissue, reducing fat bulging into the skin and the appearance of cellulite. It has been investigated for cellulite in randomised, double-blind, placebo-controlled clinical trials with 20 women.

Within eight weeks, the skin structure was strengthened, and the hypodermal-dermal interface was flattened by 22% in four weeks. This reduced-fat protrusion into the dermis and the appearance of cellulite.

The stronger and lighter the colour, the denser the proteins. Visible are the layers of keratin in the epidermis (yellow band at left) and collagen in the dermis (wide green layer). Black pixels represent proteoglycans, lipids and water.