Home Mind & Brain Exploring Atomoxetine: A Non-Stimulant Treatment for ADHD

Exploring Atomoxetine: A Non-Stimulant Treatment for ADHD

Reading Time: 4 minutes

Atomoxetine is a medication primarily used to treat attention deficit hyperactivity disorder (ADHD) in children, adolescents, and adults. As a selective norepinephrine reuptake inhibitor (NRI), atomoxetine offers an alternative to stimulant medications, which are often the first line of treatment for ADHD. 

What is atomoxetine?

The Food and Drug Administration (FDA) approved the prescription drug atomoxetine, also known as Strattera, in 2002 for the treatment of ADHD. Unlike stimulant medications such as methylphenidate and amphetamines, which are also commonly prescribed for ADHD, atomoxetine is a non-stimulant. This makes it a viable option for individuals who may not respond well to stimulants or who experience undesirable side effects from them.

Mechanism of action

Atomoxetine works by selectively inhibiting the reuptake of norepinephrine, a neurotransmitter in the brain. Norepinephrine is involved in regulating attention, impulse control, and activity levels. By preventing the reabsorption of norepinephrine, atomoxetine increases its availability in the brain, which helps improve focus, reduce hyperactivity, and control impulsive behaviour. This mechanism differs from that of stimulant medications, which primarily increase the levels of dopamine and norepinephrine.

Benefits of atomoxetine

  • Non-stimulant option. For individuals who cannot tolerate stimulants due to side effects or medical conditions, atomoxetine offers a non-stimulant alternative. This can be particularly beneficial for people with a history of substance abuse, as atomoxetine has a lower potential for abuse.
  • Long-acting. Atomoxetine is typically taken once daily, providing 24-hour symptom control. This can improve adherence to the medication regimen, as it eliminates the need for multiple doses throughout the day.
  • Gradual onset. The effects of atomoxetine build gradually over several weeks. While this may seem like a drawback for those seeking immediate relief, it allows the body to adjust to the medication, potentially reducing the likelihood of side effects.
  • Less impact on sleep and appetite. Stimulant medications often cause insomnia and appetite suppression. Atomoxetine tends to have a milder impact on sleep and appetite, making it a preferable option for some patients.

Side effects

Like all medications, atomoxetine can cause side effects. It is important for patients and carers to be aware of these potential adverse effects in order to manage them effectively.

  • Common side effects. The most frequently reported side effects of atomoxetine include dry mouth, reduced appetite, nausea, vomiting, fatigue, and dizziness. These symptoms are generally mild and tend to decrease over time as the body adjusts to the medication.
  • Cardiovascular effects. Atomoxetine can increase heart rate and blood pressure. Patients with pre-existing cardiovascular conditions should use atomoxetine with caution, and regular monitoring of heart rate and blood pressure is recommended.
  • Psychiatric effects. Some patients may experience mood swings, irritability, or increased anxiety. In rare cases, atomoxetine has been associated with suicidal thoughts, particularly in children and adolescents. It is crucial for carers and healthcare providers to monitor for any changes in mood or behaviour.
  • Liver damage. Although rare, severe liver injury has been reported in some patients taking atomoxetine. Symptoms of liver damage include jaundice (yellowing of the skin or eyes), dark urine, and unexplained flu-like symptoms. Patients experiencing these symptoms should seek medical attention immediately.

Considerations for use

  • Initial assessment. Before starting atomoxetine, a thorough medical assessment is necessary. This includes evaluating the patient’s medical history, current medications, and any pre-existing conditions. A baseline measurement of heart rate and blood pressure should be obtained.
  • Dosage. Atomoxetine is typically started at a low dose, which is gradually increased based on the patient’s response and tolerability. The dosage is usually calculated based on the patient’s weight.
  • Monitoring. Regular follow-up appointments are important to monitor the effectiveness of the medication and any side effects. Healthcare providers will assess the patient’s progress and make any necessary adjustments to the dosage.
  • Adherence. Consistency in taking atomoxetine is crucial for its effectiveness. Patients should take the medication at the same time each day, and it can be taken with or without food. If a dose is missed, it should be taken as soon as possible, but not if it is close to the time of the next dose.
  • Long-term use. The decision to continue atomoxetine long-term should be based on a regular review of the patient’s symptoms and overall functioning. Some individuals may benefit from taking the medication for several years, while others may be able to discontinue it after a period of stability.

Comparing atomoxetine with stimulants

Stimulant medications such as Adderall (amphetamine) and Ritalin (methylphenidate) are often the first choice for treating ADHD. However, they are not suitable for everyone. Here is how atomoxetine compares with stimulants:

  • Efficacy. Both atomoxetine and stimulants are effective in managing ADHD symptoms. But stimulants tend to have a quicker onset of action, whereas atomoxetine’s effects build gradually.
  • Side effect profile. Stimulants are associated with a higher incidence of insomnia, appetite suppression, and the potential for abuse. Atomoxetine, being a non-stimulant, has a different side-effect profile, with less impact on sleep and appetite but a potential for cardiovascular effects.
  • Mechanism of action. While stimulants increase the levels of dopamine and norepinephrine, atomoxetine selectively inhibits the reuptake of norepinephrine. This difference in mechanism may influence the choice of medication based on the patient’s specific symptoms and medical history.


Atomoxetine is a valuable medication in the treatment of ADHD, offering a non-stimulant alternative to traditional stimulant medications. Its benefits include once-daily dosing, a lower potential for abuse, and a gradual onset of action. However, like any medication, it is not without side effects, and careful monitoring is essential. By understanding how atomoxetine works and considering its benefits and risks, patients and healthcare providers can make informed decisions about the most appropriate treatment for ADHD.

Sarah Mitchell, PhD is a mental health advocate and writer specialising in ADHD treatment and management

© Copyright 2014–2034 Psychreg Ltd