Home Health & Wellness Clevidipine Side Effects: What You Need to Know

Clevidipine Side Effects: What You Need to Know

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Clevidipine is a fast-acting, intravenous medication used for treating high blood pressure, particularly in critical care situations like surgeries, stroke, or hypertensive emergencies. While it is effective at reducing blood pressure, like any medication, it can also have side effects. 

Understanding Clevidipine

Clevidipine is a calcium channel blocker, which means that it works by blocking the movement of calcium into the cells of the heart and blood vessels. This action leads to the relaxation of blood vessels, allowing for a reduction in blood pressure. Clevidipine is administered intravenously, meaning that it is given directly into the bloodstream via an IV drip.

Common side effects of Clevidipine

As with any medication, Clevidipine can cause side effects. Some of the more common side effects include:

  • Headache. This can be a common side effect of Clevidipine due to its blood vessel-relaxing properties. If you experience a headache while taking Clevidipine, it’s essential to inform your healthcare provider, as they may be able to recommend ways to alleviate the discomfort.
  • Nausea. Some patients may experience nausea while receiving Clevidipine. Informing your healthcare provider about this side effect can help them determine whether it’s necessary to adjust the dosage or consider an alternative medication.
  • Swelling. Clevidipine may cause fluid retention, leading to swelling in the ankles, feet, or legs. If you notice any swelling, be sure to report it to your healthcare provider promptly.
  • Flushing. Flushing or reddening of the skin is another potential side effect of Clevidipine. This is typically harmless and will resolve on its own, but if it persists or worsens, contact your healthcare provider.
  • Dizziness. Some patients may feel dizzy or lightheaded while taking Clevidipine. This is because the medication causes a sudden drop in blood pressure. Make sure to rise slowly from a sitting or lying position to reduce the risk of dizziness.

Serious side effects and allergic reactions

While most side effects of Clevidipine are mild and manageable, there is a potential for more severe side effects or allergic reactions. It’s crucial to be aware of these and seek medical help immediately if you experience any of the following:

  • Chest pain or pressure. Although Clevidipine is used to treat high blood pressure, it can sometimes cause chest pain or pressure in some individuals. If you experience these symptoms, contact your healthcare provider or seek emergency medical attention immediately.
  • Trouble breathing or swallowing. These could be signs of an allergic reaction to Clevidipine. If you have difficulty breathing or swallowing while receiving this medication, seek emergency medical help right away.
  • Rapid or irregular heartbeat. Clevidipine can sometimes cause changes in heart rhythm. If you experience a rapid or irregular heartbeat while taking this medication, notify your healthcare provider immediately.
  • Severe dizziness or fainting. If you experience severe dizziness or fainting, it may be a sign that your blood pressure is dropping too low. Contact your healthcare provider as soon as possible.

Tips for managing side effects

If you experience side effects while taking Clevidipine, there are a few steps you can take to manage them:

  • Keep your healthcare provider informed. Always communicate any side effects you experience to your healthcare provider. They may be able to adjust your dosage or suggest alternative treatments to help alleviate these side effects.
  • Stay hydrated. Drinking plenty of water can help manage some side effects like headaches and dizziness. Make sure to discuss with your healthcare provider how much water you should be drinking based on your specific situation.
  • Get up slowly. If you experience dizziness or lightheadedness, try to rise slowly from a sitting or lying position. This can help reduce the risk of falls and further complications.
  • Monitor your blood pressure. Regularly monitoring your blood pressure at home can help you and your healthcare provider keep track of any changes and adjust your treatment plan accordingly.
  • Follow your healthcare provider’s advice. Always follow your healthcare provider’s instructions regarding your Clevidipine treatment, including the recommended dosage, IV drip rate, and any additional medications that may be prescribed to manage side effects.

When to seek medical help

If you experience any severe or concerning side effects while taking Clevidipine, it’s essential to seek medical help immediately. This can include symptoms such as chest pain, trouble breathing or swallowing, rapid or irregular heartbeat, or severe dizziness and fainting. In these situations, it’s crucial to contact your healthcare provider, visit the nearest emergency room, or call 911 for emergency assistance.


Clevidipine is an effective intravenous medication for treating high blood pressure, particularly in critical care situations. However, like all medications, it can have side effects. Understanding these side effects, as well as how to manage them and when to seek medical help, is essential to ensure a safe and successful treatment experience. Always communicate with your healthcare provider regarding any side effects or concerns, and follow their instructions carefully to optimise your Clevidipine therapy.

Tim Williamson, a psychology graduate from the University of Hertfordshire, has a keen interest in the fields of mental health, wellness, and lifestyle.

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