Matthew Broome is a consultant psychiatrist and associate editor at British Journal of Psychiatry. His research focuses on subtle psychopathological changes and states that may mark the development of major mental illnesses in adolescents and young adults.
This research is part of the wider ‘early intervention’ paradigm where the goal is to both predict the onset of illness and detect disorder at the earliest stage to provide a window for therapeutic intervention. This may improve outcome, but also provides a means to prevent the disorder developing. Studying subtle changes in experiences, prior to diagnosis, also enables an understanding of pathophysiology and how disorders develop over time.
Broome’s work to date has largely focused on the ‘at risk mental state’ for psychosis, a collection of unusual experiences that may suggest an individual is at risk of developing a psychotic disorder such as schizophrenia. With his colleagues, they have used functional and structural neuroimaging, together with cognitive neuropsychology, to examine what makes such individuals at risk for psychosis, to improve prediction of who may go on to develop the disorder, and to gain a better understanding of psychological and brain changes that may underpin the onset of the disorder. He is also particularly interested in delusions and their formation and maintenance. More recently, he has been developing research into changes in mood regulation and stability, changes that may be early markers of mood or personality disorders, as well as the relationship between psychosis and autistic spectrum disorders.
Credits: University of Oxford
Published: 08 August 2015
Last updated: 04 August 2016